ALDH8A1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of ALDH8A1 polyclonal antibody (Cat # PAB3143) in mouse liver tissue lysates (35 ug/lane). ALDH8A1 (arrow) was detected using the purified polyclonal antibody.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ALDH8A1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ALDH8A1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ALDH8A1 polyclonal antibody (Cat # PAB3143) in mouse liver tissue lysates (35 ug/lane). ALDH8A1 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — ALDH8A1
Entrez GeneID
64577Protein Accession#
NP_072090;Q9H2A2Gene Name
ALDH8A1
Gene Alias
ALDH12, DJ352A20.2, DKFZp779D2315, MGC138650
Gene Description
aldehyde dehydrogenase 8 family, member A1
Omim ID
606467Gene Ontology
HyperlinkGene Summary
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
aldehyde dehydogenase 8 family, member A1|aldehyde dehydrogenase 12|aldehyde dehydrogenase 8A1|aldehyde dehydrogenase family protein
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Interactome
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Publication Reference
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cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12.
Lin M, Napoli JL.
The Journal of Biological Chemistry 2000 Dec; 275(51):40106.
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cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12.
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