TNFRSF1B polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of TNFRSF1B expression from cell extracts with TNFRSF1B polyclonal antibody (Cat # PAB12329).
Lane 1 : MCF-7 whole cell lysate.
Lane 2 : HeLa whole cell lysate.
Lane 3 : MM453 whole cell lysate.
Lane 4 : Jurkat whole cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of TNFRSF1B on formalin fixed, paraffin embedded human intestinal cancer with TNFRSF1B polyclonal antibody (Cat # PAB12329).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TNFRSF1B.
Immunogen
A synthetic peptide corresponding to amino acids at N-terminus of human TNFRSF1B.
Host
Rabbit
Reactivity
Human
Form
Lyophilized
Purification
Immunoaffinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of TNFRSF1B expression from cell extracts with TNFRSF1B polyclonal antibody (Cat # PAB12329).
Lane 1 : MCF-7 whole cell lysate.
Lane 2 : HeLa whole cell lysate.
Lane 3 : MM453 whole cell lysate.
Lane 4 : Jurkat whole cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of TNFRSF1B on formalin fixed, paraffin embedded human intestinal cancer with TNFRSF1B polyclonal antibody (Cat # PAB12329). -
Gene Info — TNFRSF1B
Entrez GeneID
7133Gene Name
TNFRSF1B
Gene Alias
CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
Gene Description
tumor necrosis factor receptor superfamily, member 1B
Omim ID
191191Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq
Other Designations
OTTHUMP00000001784|p75 TNF receptor|soluble TNFR1B variant 1|tumor necrosis factor beta receptor|tumor necrosis factor binding protein 2|tumor necrosis factor receptor 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis.
Vielhauer V, Stavrakis G, Mayadas TN.
The Journal of Clinical Investigation 2005 May; 115(5):1199.
Application：Flow Cyt, Mouse, Mouse leukocytes.
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Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis.
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