c-Myc tag recombinant monoclonal antibody, clone 9E10
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Specifications
Product Description
Mouse recombinant monoclonal antibody raised against c-Myc tag.
Antibody Species
Mouse
Immunogen
Original antibody is raised against a synthetic peptide corresponding to amino acids 408-439 of human c-myc.
Reactivity
Human
Specificity
The epitope sequence, EQKLISEEDL, is located in aa 410-419 of human c-myc protein.
Form
Liquid
Purification
Protein A affinity purification
Isotype
IgG1, kappa
Recommend Usage
Immunofluorescence
Immunohistochemistry (Frozen sections) (5 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL)
Immunoprecipitation (10 ug/mL)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.02% Proclin 300)
Storage Instruction
Store at 4°C for up to 3 months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Immunofluorescence
Immunoprecipitation
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Gene Info — MYC
Entrez GeneID
4609Protein Accession#
P01106Gene Name
MYC
Gene Alias
bHLHe39, c-Myc
Gene Description
v-myc myelocytomatosis viral oncogene homolog (avian)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
Other Designations
avian myelocytomatosis viral oncogene homolog|myc proto-oncogene protein|v-myc avian myelocytomatosis viral oncogene homolog
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Interactomes
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Pathways
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Diseases
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